| NSF Org: |
DBI Div Of Biological Infrastructure |
| Recipient: |
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| Initial Amendment Date: | August 10, 2018 |
| Latest Amendment Date: | September 7, 2022 |
| Award Number: | 1828319 |
| Award Instrument: | Standard Grant |
| Program Manager: |
Jennifer Weller
jweller@nsf.gov (703)292-2224 DBI Div Of Biological Infrastructure BIO Direct For Biological Sciences |
| Start Date: | October 1, 2018 |
| End Date: | September 30, 2022 (Estimated) |
| Total Intended Award Amount: | $1,589,334.00 |
| Total Awarded Amount to Date: | $1,589,334.00 |
| Funds Obligated to Date: |
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| History of Investigator: |
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| Recipient Sponsored Research Office: |
51 COLLEGE RD DURHAM NH US 03824-2620 (603)862-2172 |
| Sponsor Congressional District: |
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| Primary Place of Performance: |
105 Main Street Durham NH US 03824-3585 |
| Primary Place of Performance Congressional District: |
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| Unique Entity Identifier (UEI): |
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| Parent UEI: |
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| NSF Program(s): | Major Research Instrumentation |
| Primary Program Source: |
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| Program Reference Code(s): |
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| Program Element Code(s): |
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| Award Agency Code: | 4900 |
| Fund Agency Code: | 4900 |
| Assistance Listing Number(s): | 47.074 |
ABSTRACT
An award is made to the University of New Hampshire (UNH) to support the acquisition of a 700 MHz Nuclear Magnetic Resonance (NMR) spectrometer. The 700 MHz NMR will be configured for solution and solid state NMR studies with high sensitivity and ease-of-use to enable structural and dynamics studies of biological and other low sensitivity molecules. The new instrument will serve 18 UNH research programs from 6 departments and 3 colleges, bringing together a diverse group of researchers. It will also serve other colleges and universities in the region and will be nationally accessible via remote login. The instrument will enhance advanced training opportunities, especially for students pursuing advanced degrees, preparing the next generation of NMR spectroscopists.
Research enabled by the acquisition encompasses a broad range of structural biology, chemistry, and materials science based projects at UNH and in the northern New England region. Research topics will include studies of antifreeze proteins, scaffold proteins, photoreceptor enzymes, synthetic enzymes, elastin-like polymers, and protein-polymer hybrids. NMR data will be integrated with modelling and simulation data to gain a holistic view of protein dynamics and interactions. Solid state NMR will be used to characterize the structure and dynamics of solid samples, including membrane associated proteins, protein-ice mixtures, polymers, and nanomaterials. Data from these studies will be published in peer-reviewed journals, presented at scientific meetings, used in course offerings, and leveraged in public outreach activities.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
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PROJECT OUTCOMES REPORT
Disclaimer
This Project Outcomes Report for the General Public is displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed in this Report are those of the PI and do not necessarily reflect the views of the National Science Foundation; NSF has not approved or endorsed its content.
The University of New Hampshire (UNH) purchased a Bruker AVANCE NEO 700 MHz Nuclear Magnetic Resonance (NMR) spectrometer, and the installation was completed in the fall of 2019. The instrument was placed at the University Instrumentation Center, a shared facility managed by expert staff. The instrument has provided a significant improvement in infrastructure, and it is available for use to researchers at UNH, the wider Northern New England, area as well as nationwide due to its remote login capabilities. The NMR instrument is equipped with a variety of probes to support diverse research projects, including a high sensitivity solution CryoProbe and solid state NMR probes.
NMR is one of the most versatile spectroscopic techniques and provides a wealth of information about molecular structure, motion, and interactions. The 700 MHz NMR made structural studies of biological and other low sensitivity molecules feasible. Research that has been enabled include a wide variety of structural biology, chemistry, and material science research projects at UNH and the regional scientific community: proteins, polymers, nanomaterials, as well as small organic compounds. These projects greatly benefitted from a modern 700 MHz NMR, including the boost in sensitivity, resolution, multidimensional NMR capabilities, and ease-of-use of the instrument. The results from the research were disseminated to the public via articles in peer-reviewed journals, presented at scientific meetings, used in course offerings, and leveraged in public outreach activities.
With over 15,000 students, UNH is the largest public research university in NH and one of two universities to offer PhD degrees in chemistry and the biological sciences. UNH plays a major role in STEM education in NH and in workforce development, and the NMR instrument has significantly enhanced advanced training opportunities, especially for students pursuing advanced degrees. A comprehensive NMR user-training program has addressed the needs of novice through expert users. This instrument has so far served 14 research programs at UNH as well as other users at the Northern New England area. We anticipate that the NMR will continue having a positive impact on research productivity across campus and regionally, well beyond the reporting years of this project.
Last Modified: 02/08/2023
Modified by: Krisztina Varga
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700 MHz NMR at the University of Hew Hampshire.Krisztina VargaPublic DomainKrisztina Varga700 MHz NMR
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