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Wu L, Lin Q, Chatla S, Amarachintha S, Wilson AF, Atale N, Gao ZJ, Joseph J, Wolff EV, Du W. LepR+ niche cell-derived AREG compromises hematopoietic stem cell maintenance under conditions of DNA repair deficiency and aging. Blood. 2023 Nov 2;142(18):1529-1542. doi: 10.1182/blood.2022018212. PubMed PMID: 37584437; PubMed Central PMCID: PMC10656728.
Li X, Chatla S, Wilson AF, Wu L, Atale N, Du W. Persistent DNA damage and oncogenic stress-induced Trem1 promotes leukemia in mice. Haematologica. 2022 Nov 1;107(11):2576-2588. doi: 10.3324/haematol.2021.280404. PubMed PMID: 35443564; PubMed Central PMCID: PMC9614537.
Lin Q, Wu L, Chatla S, Chowdhury FA, Atale N, Joseph J, Du W. Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis. J Clin Invest. 2022 Jun 15;132(12). doi: 10.1172/JCI155914. PubMed PMID: 35703178; PubMed Central PMCID: PMC9197516.
Zhan S, Siu J, Wang Z, Yu H, Bezabeh T, Deng Y, Du W, Fei P. Focal Point of Fanconi Anemia Signaling. Int J Mol Sci. 2021 Nov 30;22(23). doi: 10.3390/ijms222312976. Review. PubMed PMID: 34884777; PubMed Central PMCID: PMC8657418.
Wu L, Chatla S, Lin Q, Chowdhury FA, Geldenhuys W, Du W. Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia. Nat Commun. 2021 Nov 26;12(1):6936. doi: 10.1038/s41467-021-27300-w. PubMed PMID: 34836965; PubMed Central PMCID: PMC8626516.
Wu L, Li X, Lin Q, Chowdhury F, Mazumder MH, Du W. FANCD2 and HES1 suppress inflammation-induced PPARɣ to prevent haematopoietic stem cell exhaustion. Br J Haematol. 2021 Feb;192(3):652-663. doi: 10.1111/bjh.17230. Epub 2020 Nov 22. PubMed PMID: 33222180; PubMed Central PMCID: PMC7856217.
Wu L, Lin Q, Ma Z, Chowdhury FA, Mazumder MHH, Du W. Mesenchymal PGD(2) activates an ILC2-Treg axis to promote proliferation of normal and malignant HSPCs. Leukemia. 2020 Nov;34(11):3028-3041. doi: 10.1038/s41375-020-0843-8. Epub 2020 May 4. PubMed PMID: 32366935; PubMed Central PMCID: PMC7606225.
Ma Z, Xu J, Wu L, Wang J, Lin Q, Chowdhury FA, Mazumder MHH, Hu G, Li X, Du W. Hes1 deficiency causes hematopoietic stem cell exhaustion. Stem Cells. 2020 Jun;38(6):756-768. doi: 10.1002/stem.3169. Epub 2020 Mar 16. PubMed PMID: 32129527; PubMed Central PMCID: PMC7260087.
Lin Q, Wu L, Ma Z, Chowdhury FA, Mazumder HH, Du W. Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function. JCI Insight. 2020 May 21;5(10). doi: 10.1172/jci.insight.133365. PubMed PMID: 32434992; PubMed Central PMCID: PMC7259522.
Chatla S, Du W, Wilson AF, Meetei AR, Pang Q. Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation. Stem Cell Res. 2019 Oct;40:101550. doi: 10.1016/j.scr.2019.101550. Epub 2019 Aug 23. PubMed PMID: 31472450; PubMed Central PMCID: PMC6907690.
Li X, Wu L, Zopp M, Kopelov S, Du W. p53-TP53-Induced Glycolysis Regulator Mediated Glycolytic Suppression Attenuates DNA Damage and Genomic Instability in Fanconi Anemia Hematopoietic Stem Cells. Stem Cells. 2019 Jul;37(7):937-947. doi: 10.1002/stem.3015. Epub 2019 May 3. PubMed PMID: 30977208; PubMed Central PMCID: PMC6599562.
Liu W, Du W, Shang X, Wang L, Evelyn C, Florian MC, A Ryan M, Rayes A, Zhao X, Setchell K, Meller J, Guo F, Nassar N, Geiger H, Pang Q, Zheng Y. Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Leukemia. 2019 Mar;33(3):749-761. doi: 10.1038/s41375-018-0251-5. Epub 2018 Sep 25. PubMed PMID: 30254339; PubMed Central PMCID: PMC6414073.
Wu L, Amarachintha S, Xu J, Oley F Jr, Du W. Mesenchymal COX2-PG secretome engages NR4A-WNT signalling axis in haematopoietic progenitors to suppress anti-leukaemia immunity. Br J Haematol. 2018 Nov;183(3):445-456. doi: 10.1111/bjh.15548. Epub 2018 Aug 14. PubMed PMID: 30106181; PubMed Central PMCID: PMC6391996.
Du W, Liu W, Mizukawa B, Shang X, Sipple J, Wunderlich M, Geiger H, Davies S, Mulloy J, Pang Q, Zheng Y. A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells. Leukemia. 2018 Sep;32(9):2041-2046. doi: 10.1038/s41375-018-0200-3. Epub 2018 Jun 29. PubMed PMID: 29959415; PubMed Central PMCID: PMC6128741.
Du W, Li X, Wilson AF, Pang Q. A small molecule p53 activator attenuates Fanconi anemia leukemic stem cell proliferation. Stem Cell Res Ther. 2018 May 22;9(1):145. doi: 10.1186/s13287-018-0882-5. PubMed PMID: 29784053; PubMed Central PMCID: PMC5963145.
Xu J, Li X, Cole A, Sherman Z, Du W. Reduced Cell Division Control Protein 42 Activity Compromises Hematopoiesis-Supportive Function of Fanconi Anemia Mesenchymal Stromal Cells. Stem Cells. 2018 May;36(5):785-795. doi: 10.1002/stem.2789. Epub 2018 Feb 9. PubMed PMID: 29377497; PubMed Central PMCID: PMC5918239.
Li X, Wilson AF, Du W, Pang Q. Cell-Cycle-Specific Function of p53 in Fanconi Anemia Hematopoietic Stem and Progenitor Cell Proliferation. Stem Cell Reports. 2018 Feb 13;10(2):339-346. doi: 10.1016/j.stemcr.2017.12.006. Epub 2018 Jan 4. PubMed PMID: 29307578; PubMed Central PMCID: PMC5830889.
Li Y, Li X, Cole A, McLaughlin S, Du W. Icariin improves Fanconi anemia hematopoietic stem cell function through SIRT6-mediated NF-kappa B inhibition. Cell Cycle. 2018;17(3):367-376. doi: 10.1080/15384101.2018.1426413. Epub 2018 Feb 8. PubMed PMID: 29355456; PubMed Central PMCID: PMC5914729.
Wu L, Cole A, Du W. Immune-DDR crosstalk in pre-leukemia stem cells. Oncotarget. 2017 Oct 10;8(47):81731-81732. doi: 10.18632/oncotarget.21047. eCollection 2017 Oct 10. PubMed PMID: 29137216; PubMed Central PMCID: PMC5669842.
Li Y, Amarachintha S, Wilson AF, Li X, Du W. Persistent response of Fanconi anemia haematopoietic stem and progenitor cells to oxidative stress. Cell Cycle. 2017 Jun 18;16(12):1201-1209. doi: 10.1080/15384101.2017.1320627. Epub 2017 May 5. PubMed PMID: 28475398; PubMed Central PMCID: PMC5499909.
Sertorio M, Du W, Amarachintha S, Wilson A, Pang Q. In Vivo RNAi Screen Unveils PPARγ as a Regulator of Hematopoietic Stem Cell Homeostasis. Stem Cell Reports. 2017 May 9;8(5):1242-1255. doi: 10.1016/j.stemcr.2017.03.008. Epub 2017 Apr 13. PubMed PMID: 28416286; PubMed Central PMCID: PMC5425620.
Zhang T, Du W, Wilson AF, Namekawa SH, Andreassen PR, Meetei AR, Pang Q. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Sci Rep. 2017 Apr 5;7:45626. doi: 10.1038/srep45626. PubMed PMID: 28378742; PubMed Central PMCID: PMC5381226.
Du W, Amarachintha S, Wilson A, Pang Q. The immune receptor Trem1 cooperates with diminished DNA damage response to induce preleukemic stem cell expansion. Leukemia. 2017 Feb;31(2):423-433. doi: 10.1038/leu.2016.242. Epub 2016 Aug 29. PubMed PMID: 27568523; PubMed Central PMCID: PMC7163296.
Du W, Amarachintha S, Erden O, Wilson A, Pang Q. The Fanconi anemia pathway controls oncogenic response in hematopoietic stem and progenitor cells by regulating PRMT5-mediated p53 arginine methylation. Oncotarget. 2016 Sep 13;7(37):60005-60020. doi: 10.18632/oncotarget.11088. PubMed PMID: 27507053; PubMed Central PMCID: PMC5312365.
Wang Y, Chang J, Shao L, Feng W, Luo Y, Chow M, Du W, Meng A, Zhou D. Hematopoietic Stem Cells from Ts65Dn Mice Are Deficient in the Repair of DNA Double-Strand Breaks. Radiat Res. 2016 Jun;185(6):630-7. doi: 10.1667/RR14407.1. Epub 2016 May 31. PubMed PMID: 27243896; PubMed Central PMCID: PMC4943077.
Du W, Amarachintha S, Wilson AF, Pang Q. SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells. Stem Cells. 2016 Apr;34(4):960-71. doi: 10.1002/stem.2260. Epub 2015 Dec 31. PubMed PMID: 26676373; PubMed Central PMCID: PMC4838537.
Du W, Amarachintha S, Wilson AF, Pang Q. Hyper-active non-homologous end joining selects for synthetic lethality resistant and pathological Fanconi anemia hematopoietic stem and progenitor cells. Sci Rep. 2016 Feb 26;6:22167. doi: 10.1038/srep22167. PubMed PMID: 26916217; PubMed Central PMCID: PMC4768158.
Du W, Amarachintha S, Erden O, Wilson A, Meetei AR, Andreassen PR, Namekawa SH, Pang Q. Fancb deficiency impairs hematopoietic stem cell function. Sci Rep. 2015 Dec 11;5:18127. doi: 10.1038/srep18127. PubMed PMID: 26658157; PubMed Central PMCID: PMC4676042.
Looi CY, Sasahara Y, Watanabe Y, Satoh M, Hakozaki I, Uchiyama M, Wong WF, Du W, Uchiyama T, Kumaki S, Tsuchiya S, Kure S. The open conformation of WASP regulates its nuclear localization and gene transcription in myeloid cells. Int Immunol. 2014 Jun;26(6):341-52. doi: 10.1093/intimm/dxt072. Epub 2014 Jan 8. PubMed PMID: 24402308.
Li X, Erden O, Li L, Ye Q, Wilson A, Du W. Binding to WGR domain by salidroside activates PARP1 and protects hematopoietic stem cells from oxidative stress. Antioxid Redox Signal. 2014 Apr 20;20(12):1853-65. doi: 10.1089/ars.2013.5600. Epub 2014 Mar 5. PubMed PMID: 24294904; PubMed Central PMCID: PMC3967359.
Du W, Erden O, Wilson A, Sipple JM, Schick J, Mehta P, Myers KC, Steinbrecher KA, Davies SM, Pang Q. Deletion of Fanca or Fancd2 dysregulates Treg in mice. Blood. 2014 Mar 20;123(12):1938-47. doi: 10.1182/blood-2013-09-528018. Epub 2014 Feb 5. PubMed PMID: 24501220; PubMed Central PMCID: PMC3962166.
Guo F, Li J, Zhang S, Du W, Amarachintha S, Sipple J, Phelan J, Grimes HL, Zheng Y, Pang Q. mTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression. Leukemia. 2014 Jan;28(1):203-6. doi: 10.1038/leu.2013.215. Epub 2013 Jul 15. PubMed PMID: 23852546; PubMed Central PMCID: PMC3947286.
Du W, Erden O, Pang Q. TNF-α signaling in Fanconi anemia. Blood Cells Mol Dis. 2014 Jan;52(1):2-11. doi: 10.1016/j.bcmd.2013.06.005. Epub 2013 Jul 24. Review. PubMed PMID: 23890415; PubMed Central PMCID: PMC3851925.
Guo F, Li J, Du W, Zhang S, O'Connor M, Thomas G, Kozma S, Zingarelli B, Pang Q, Zheng Y. mTOR regulates DNA damage response through NF-κB-mediated FANCD2 pathway in hematopoietic cells. Leukemia. 2013 Oct;27(10):2040-2046. doi: 10.1038/leu.2013.93. Epub 2013 Mar 29. PubMed PMID: 23538752; PubMed Central PMCID: PMC4225699.
Guo F, Zhang S, Grogg M, Cancelas JA, Varney ME, Starczynowski DT, Du W, Yang JQ, Liu W, Thomas G, Kozma S, Pang Q, Zheng Y. Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis. Haematologica. 2013 Sep;98(9):1353-8. doi: 10.3324/haematol.2012.080424. Epub 2013 May 28. PubMed PMID: 23716557; PubMed Central PMCID: PMC3762090.
Du W, Amarachintha S, Sipple J, Schick J, Steinbrecher K, Pang Q. Inflammation-mediated notch signaling skews fanconi anemia hematopoietic stem cell differentiation. J Immunol. 2013 Sep 1;191(5):2806-17. doi: 10.4049/jimmunol.1203474. Epub 2013 Aug 7. PubMed PMID: 23926327; PubMed Central PMCID: PMC3773980.
Li X, Sipple J, Pang Q, Du W. Salidroside stimulates DNA repair enzyme Parp-1 activity in mouse HSC maintenance. Blood. 2012 May 3;119(18):4162-73. doi: 10.1182/blood-2011-10-387332. Epub 2012 Mar 16. PubMed PMID: 22427203; PubMed Central PMCID: PMC3359737.
Du W, Rani R, Sipple J, Schick J, Myers KC, Mehta P, Andreassen PR, Davies SM, Pang Q. The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters. Blood. 2012 May 3;119(18):4142-51. doi: 10.1182/blood-2011-09-381970. Epub 2012 Mar 9. PubMed PMID: 22408259; PubMed Central PMCID: PMC3359736.
Du W, Li XE, Sipple J, Pang Q. Overexpression of IL-3Rα on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AML. Blood. 2011 Apr 21;117(16):4243-52. doi: 10.1182/blood-2010-09-309179. Epub 2011 Feb 17. PubMed PMID: 21330473; PubMed Central PMCID: PMC3087476.
Du W. Inflammatory ROS in Fanconi Anemia Hematopoiesis and Leukemogenesis. In: Cancer prevention InTech Open: InTech; 2011. Chapter 2;
Du W, Li J, Sipple J, Chen J, Pang Q. Cytoplasmic FANCA-FANCC complex interacts and stabilizes the cytoplasm-dislocalized leukemic nucleophosmin protein (NPMc). J Biol Chem. 2010 Nov 26;285(48):37436-44. doi: 10.1074/jbc.M110.113209. Epub 2010 Sep 23. PubMed PMID: 20864535; PubMed Central PMCID: PMC2988349.
Li J, Du W, Maynard S, Andreassen PR, Pang Q. Oxidative stress-specific interaction between FANCD2 and FOXO3a. Blood. 2010 Feb 25;115(8):1545-8. doi: 10.1182/blood-2009-07-234385. Epub 2009 Dec 29. PubMed PMID: 20040763; PubMed Central PMCID: PMC2830760.
Du W, Zhou Y, Pike S, Pang Q. NPM phosphorylation stimulates Cdk1, overrides G2/M checkpoint and increases leukemic blasts in mice. Carcinogenesis. 2010 Feb;31(2):302-10. doi: 10.1093/carcin/bgp270. Epub 2009 Nov 23. PubMed PMID: 19933706; PubMed Central PMCID: PMC2812569.
Du W, Adam Z, Rani R, Zhang X, Pang Q. Oxidative stress in Fanconi anemia hematopoiesis and disease progression. Antioxid Redox Signal. 2008 Nov;10(11):1909-21. doi: 10.1089/ars.2008.2129. Review. PubMed PMID: 18627348; PubMed Central PMCID: PMC2695607.
Zhou Y, Du W, Koretsky T, Bagby GC, Pang Q. TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice. Blood. 2008 Sep 15;112(6):2474-83. doi: 10.1182/blood-2007-12-130211. Epub 2008 Jun 23. PubMed PMID: 18574026; PubMed Central PMCID: PMC2532814.
Du W, Kumaki S, Uchiyama T, Yachie A, Yeng Looi C, Kawai S, Minegishi M, Ramesh N, Geha RS, Sasahara Y, Tsuchiya S. A second-site mutation in the initiation codon of WAS (WASP) results in expansion of subsets of lymphocytes in an Wiskott-Aldrich syndrome patient. Hum Mutat. 2006 Apr;27(4):370-5. doi: 10.1002/humu.20308. PubMed PMID: 16511828.
Uchiyama T, Kumaki S, Ishikawa Y, Onodera M, Sato M, Du W, Sasahara Y, Tanaka N, Sugamura K, Tsuchiya S. Application of HSVtk suicide gene to X-SCID gene therapy: ganciclovir treatment offsets gene corrected X-SCID B cells. Biochem Biophys Res Commun. 2006 Mar 10;341(2):391-8. doi: 10.1016/j.bbrc.2005.12.199. Epub 2006 Jan 11. PubMed PMID: 16426573.
Uchiyama T, Kumaki S, Fujiwara M, Nishida Y, Hakozaki I, Imai K, Du W, Yoshinari M, Sasahara Y, Tsuchiya S. A novel JAK3 mutation in a Japanese patient with severe combined immunodeficiency. Pediatr Int. 2005 Oct;47(5):575-8. doi: 10.1111/j.1442-200x.2005.02103.x. PubMed PMID: 16190968.
Jo EK, Kumaki S, Wei D, Tsuchiya S, Kanegane H, Song CH, Noh HY, Kim YO, Kim SY, Chung HY, Kim YH, Kook H. X-linked severe combined immunodeficiency syndrome: the first Korean case with gamma c chain gene mutation and subsequent genetic counseling. J Korean Med Sci. 2004 Feb;19(1):123-6. doi: 10.3346/jkms.2004.19.1.123. PubMed PMID: 14966353; PubMed Central PMCID: PMC2822247.
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