LepR+ niche cell-derived AREG compromises hematopoietic stem cell maintenance under conditions of DNA repair deficiency and aging.
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Persistent DNA damage and oncogenic stress-induced Trem1 promotes leukemia in mice.
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Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis.
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Focal Point of Fanconi Anemia Signaling.
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Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia.
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FANCD2 and HES1 suppress inflammation-induced PPARɣ to prevent haematopoietic stem cell exhaustion.
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Mesenchymal PGD(2) activates an ILC2-Treg axis to promote proliferation of normal and malignant HSPCs.
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Hes1 deficiency causes hematopoietic stem cell exhaustion.
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Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function.
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Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation.
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p53-TP53-Induced Glycolysis Regulator Mediated Glycolytic Suppression Attenuates DNA Damage and Genomic Instability in Fanconi Anemia Hematopoietic Stem Cells.
Stem Cells.
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Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization.
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Mesenchymal COX2-PG secretome engages NR4A-WNT signalling axis in haematopoietic progenitors to suppress anti-leukaemia immunity.
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A small molecule p53 activator attenuates Fanconi anemia leukemic stem cell proliferation.
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Reduced Cell Division Control Protein 42 Activity Compromises Hematopoiesis-Supportive Function of Fanconi Anemia Mesenchymal Stromal Cells.
Stem Cells.
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Icariin improves Fanconi anemia hematopoietic stem cell function through SIRT6-mediated NF-kappa B inhibition.
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Persistent response of Fanconi anemia haematopoietic stem and progenitor cells to oxidative stress.
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In Vivo RNAi Screen Unveils PPARγ as a Regulator of Hematopoietic Stem Cell Homeostasis.
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Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
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The immune receptor Trem1 cooperates with diminished DNA damage response to induce preleukemic stem cell expansion.
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The Fanconi anemia pathway controls oncogenic response in hematopoietic stem and progenitor cells by regulating PRMT5-mediated p53 arginine methylation.
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Hematopoietic Stem Cells from Ts65Dn Mice Are Deficient in the Repair of DNA Double-Strand Breaks.
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Hyper-active non-homologous end joining selects for synthetic lethality resistant and pathological Fanconi anemia hematopoietic stem and progenitor cells.
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Fancb deficiency impairs hematopoietic stem cell function.
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The open conformation of WASP regulates its nuclear localization and gene transcription in myeloid cells.
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Binding to WGR domain by salidroside activates PARP1 and protects hematopoietic stem cells from oxidative stress.
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mTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression.
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