Correlation of Best Corrected Visual Acuity and Central Subfield Thickness in Macular Edema Due to Retinal Vein Occlusion, Diabetic Retinopathy and Uveitis

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D. Grewal, Ophthalmology, Duke Eye Center, Durham, North Carolina, UNITED STATES|T.A. Ciulla, B. Kapik, Clearside Biomedical, Inc., Georgia, UNITED STATES|T.A. Ciulla, Indiana University School of Medicine, Indiana, UNITED STATES|

Tag(s) 2020 Annual Meeting, MOI: Multidisciplinary Ophthalmic Imaging Group, Scientific presentation

Correlation of Best Corrected Visual Acuity and Central Subfield Thickness in Macular Edema Due to Retinal Vein Occlusion, Diabetic Retinopathy and Uveitis

Description

Purpose:
Given the clinical importance of best corrected visual acuity (BCVA) and macular edema (ME) quantitated from OCT central subfield thickness (CST), this study assessed the relationship between BCVA and CST in ME due to retinal vein occlusion (RVO), diabetic retinopathy (DME) and noninfectious uveitis (NIU).
Methods:
This post hoc analysis of eyes with ME due to RVO, DME, or NIU assessed the relationship between BCVA and CST in ME across three disease states, in 6 clinical trials, with monitor-verified diagnoses per eligibility criteria, Early Treatment Diabetic Retinopathy Study (ETDRS) protocol refractions and OCT reading center evaluation. Patients were assessed at monthly intervals for up to 6 months, independent of randomization to the active or control arm of the clinical trial. The two clinical trials for each of the thee disorders were analyzed separately and analyzed pooled by disorder. Correlation and univariate regression analyses were performed to assess relationships between ETDRS BCVA and CST.
Results:
This analysis included 1,063 eyes with ME due to RVO (774 eyes), DME (91 eyes) and NIU (198 eyes). With respect to baseline BCVA and CST, Pearson Correlation Coefficients were: ME due to RVO -0.56 (95% CI -0.61 to -0.51, P <0.001), DME -0.50 (95% CI -0.64 to -0.33, P <0.001), and ME due to NIU -0.55 (95% CI -0.49 to -0.26, P <0.001). When correlating change from baseline to 6 months for both BCVA and CST, Pearson Correlation Coefficients were: ME due to RVO -0.35 (95% CI -0.43 to -0.27, P <0.001), DME -0.30 (95% CI -0.48 to -0.09, P =0.006), and ME due to NIU -0.40 (95% CI -0.53 to -0.29, P <0.001).
Conclusions:
In this cohort of over 1000 eyes, there were moderate relationships between BCVA and CST in patients with ME due to RVO, DME and NIU at baseline and these were similar across disease states. There were also moderate relationships between BCVA and CST across these disease states with respect to change from baseline to 6 months. These correlations provide context around the use of CST in clinical decision making and visual recovery.

Dilraj Grewal: Commercial Relationship(s);EyePoint:Code C (Consultant);Clearside:Code C (Consultant);Alimera:Code C (Consultant);DORC:Code C (Consultant) | Thomas Ciulla: Commercial Relationship(s);Clearside Biomedical, Inc.:Code E (Employment);Clearside Biomedical, Inc.:Code I (Personal Financial Interest) | Barry Kapik: Commercial Relationship(s);Clearside Biomedical, Inc.:Code E (Employment);Clearside Biomedical, Inc.:Code I (Personal Financial Interest)