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We begin at the beginning, with an outline of Aristotle’s views on ontology and with a discussion of the influence of these views on Linnaeus. We move from there to consider the data standardization initiatives launched in the nineteenth century and then turn to investigate how the idea of computational ontologies developed in the AI and knowledge representation communities in the closing decades of the twentieth century. We show how aspects of this idea, particularly those relating to the use of the term “concept” in ontology development, influenced SNOMED CT and other medical terminologies. Against this background, we then show how the Foundational Model of Anatomy, the Gene Ontology, Basic Formal Ontology, and other OBO Foundry ontologies came into existence and discuss their role in the development of contemporary biomedical informatics. Keywords: biomedical ontology, Aristotle, Linnaeus …