Start:
November 15, 2021
End:
November 2023
Enrollment:
414
This Phase 2 study will test the safety and effectiveness of varoglutamstat to reduce amyloid deposits in older adults with early-stage Alzheimer's disease. In the first phase of this study, participants will be randomly assigned to receive one of three dosage levels of the study drug or a placebo by tablet twice a day for six months. In the second phase, participants will take the highest safe dose identified in the first phase and researchers will assess the longer term effects of the study drug up to 72 weeks. At the end of each study phase, researchers will measure any changes in brain activity, and cognitive and daily functioning. They will also collect blood and cerebral spinal fluid samples to analyze drug absorption and any changes in the levels of amyloid protein. Throughout the study, participants will be monitored for any adverse health events.
Minimum Age: 50 Years
Maximum Age: 89 Years
Contact study personnel listed either under the general study contact or the location nearest you.
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Arizona | |
---|---|
Barrow Neurological Institute
Phoenix,
AZ
85013
Recruiting
| |
Banner Sun Health Research Institute
Sun City,
AZ
85351
Recruiting
| |
California | |
The Neuron Clinic
Chula Vista,
CA
91910
Recruiting
| |
University of California
Irvine,
CA
92868
Recruiting
| |
UCSD Alzheimer's Disease Research Center
La Jolla,
CA
92037
Recruiting
| |
Cedars-Sinai Center
Los Angeles,
CA
90048
Recruiting
| |
PCND Neurology
Poway,
CA
92064
Recruiting
| |
District of Columbia | |
Georgetown University Medical Center
Washington,
DC
20057
Recruiting
| |
Florida | |
USF Health Byrd Alzheimer's Center and Research Institute
Tampa,
FL
33613
Recruiting
| |
Georgia | |
Emory University
Atlanta,
GA
30329
Recruiting
| |
Illinois | |
Northwestern University Feinberg School of Medicine
Chicago,
IL
60611
Recruiting
| |
Iowa | |
The University of Iowa Carver College of Medicine
Iowa City,
IA
52242
Recruiting
| |
Kentucky | |
The University of Kentucky Sanders-Brown Center on Aging
Lexington,
KY
40504
Recruiting
| |
Maine | |
Northern Light Acadia Hospital
Bangor,
ME
04401
Recruiting
| |
New York | |
NYU Langone Health Tisch Hospital
New York,
NY
10016
Recruiting
| |
SUNY Upstate Medical University
Syracuse,
NY
13210
Recruiting
| |
Ohio | |
Ohio State University
Columbus,
OH
43210
Recruiting
| |
Oregon | |
OHSU Neurology Clinic
Portland,
OR
97239
Recruiting
| |
Pennsylvania | |
Abington Neurological Associates
Abington,
PA
19001
Recruiting
| |
Rhode Island | |
Rhode Island Hospital
Providence,
RI
02903
Recruiting
| |
South Carolina | |
Lowcountry Center for Veterans Research (LCVR)
Charleston,
SC
29403
Recruiting
| |
Texas | |
UT Health San Antonio
San Antonio,
TX
78229
Recruiting
|
Lead: Vivoryon Therapeutics N.V.
Collaborator Sponsor
Source: ClinicalTrials.gov ID: NCT03919162
An official website of the U.S. government, managed by the National Institute on Aging at the National Institutes of Health