Ewing's U - A Systems Biology Approach to Identifying Targetable Vulnerabilities in Ewing Sarcoma
Pediatric oncologist Dr. Filemon Dela Cruz of MSK discusses how cutting-edge Tumor Sequencing and Bionformatics paired with AI modeling can help find druggable master regulators (chokepoints) in Ewing Sarcoma.
Drugging The “Undruggable” - A New Grant from Little Warrior
Little Warrior Foundation grants $130,000 to John Bushweller, PhD, at the University of Virginia, to further optimize a small molecule inhibitor for ETS driven cancers like Ewing Sarcoma.
Ewing’s U: Dr. Thomas Sharschmidt: Advancements in surgical interventions for sarcoma patients
Orthooncologist Dr. Thomas Scharschmidt of Nationwide Children's discusses multiple cutting-edge surgical options that are now available to kids with Ewing Sarcoma, with the ultimate aim of using modern technology to improve patient outcomes.
Ewings U: Dr. Federico Clinical Trial Update on ONITT & ANGIO-A
Dr. Federico provided updates on two unique clinical trials underway at St. Jude Children’s Research Hospital: ONITT and Angio-A.
Ewings U: Dr. Loeb on DFMO for Ewing's Sarcoma
Dr. Loeb shared the results of his research in animal models and talked about the potential of this drug for Ewing Sarcoma.
Ewing's U: Dr. Grohar Clinical Trial Update on Trabectedin and Irinotecan
Dr. Grohar provides an update on Phase I results of SARC037 – a clinical trial of Trabectedin in combination with Irinotecan. We also touch on the recently opened study at CHOP utilizing a similar targeted agent, Lurbinectedin.
Ewings U: Decision Aid for Surgical Options in the Lower Extremity with Janet Panoch, PhD
Warrior Mom turned Researcher Janet Panoch PhD discusses her newly released Surgical Decision Aid. Although geared specifically towards Osteosarcoma, this decision aid is equally applicable to those with Ewing Sarcoma.
Local Astronauts Host Garage Sales To Raise Money For New Space Suits
“Our suits haven’t improved in over 40 years. Even when they are at their best, we still suffer long term health effects,” said Scott Banyan, NASA’s chief astronaut. “And frankly, sometimes they just don’t work. I’ve lost a lot of colleagues to these dangerous, antiquated suits.”
BostonGene and Little Warrior Foundation Collaborate to Bring Novel Liquid Biopsy Solutions into Clinical Practice
BostonGene today announced a collaboration with Little Warrior Foundation to drive the discovery, validation, and implementation of novel liquid biopsy solutions into sarcoma clinical practice.
Ewing's U: Dr. Trovillion + Patient Parents on Precision Medicine
We spoke with talk with Dr. Erin Trovillion about the clinical side of the In:Formation Project, a precision medicine program. We were also fortunate to be joined the parents of an 11 year-old who is enrolled in the In:Formation Project.
Ewing's U: Dr. Margolis on Bone Marrow Transplant for Ewing Sarcoma
In February, we talked to Dr. Margolis of Children’s Wisconsin about the use of Bone Marrow Transplant as a treatment option for Ewing Sarcoma. We heard about factors to consider, approaches, and expectations.
New Trial: SBRT and the Immune System
Dr. Erin Murphy of the Cleveland Clinic is offering a new observational clinical trial (where patients are treated and then followed over time) to patients with recurrent or metastatic sarcoma who are eligible to receive SBRT.
Funding Hope for Kids Like Brynn: $250,000 to the In:Formation Project
When we wrote a second $250,000 check to continue funding the In:Fromation Project, we did so with glee. Of course, we’re big on scrutiny and we’re careful with cash. But this initiative is making a powerful impact today and delivering hope and options to the warriors who need it most.
Ewing's U: Dr. Claudia Rössig on CAR-T Therapy for Ewing's Sarcoma
Dr. Claudia Rössig joined Ewings U to discuss her novel CAR-T Therapy development for Ewing Sarcoma.
Previous CAR-T research has fallen short for Ewing Sarcoma patients. However, Dr. Rössig's lab has identified a promising new approach that will be entering a Phase I Clinical Trial this year.
Ewing's U: Dr. Nelson | Children's National Medical Center
Dr. Nelson speaks with the Little Warrior Foundation about Cryoablation in solid tumors and the innovative clinical trial she is leading at Children’s National Medical Center. (Clinical Trial: NCT05302921)
$2,000,000 in Hot Tub Research
Childhood Cancer have you stressed? The NIH has your back! They’ve invested $2,04,704 to see if sitting in a hot tub will reduce stress. Sweet relief! We’re rolling our eyes past the point of no return.
Giving Tuesday: Start A Fundraiser Honoring a Little Warrior
This Giving Tuesday, we’re encouraging people to raise money for research in honor of – or memory of – a Little Warrior in their life! We provide all the tools to create your personalized fundraising experience!
Ewing's U: Matteo Trucco, MD | National Ewing Sarcoma Tumor Board
Dr. Matteo Trucco discussed the National Ewing Sarcoma Tumor Board with the Little Warrior Foundation Co-Founders.
Ewings U: Ramon Sun, PhD | Leveraging Next Generation Spatial Technologies to Identify Actionable Targets in Ewing's Sarcoma
Dr. Ramon Sun discusses how his lab uses cutting-edge analytical techniques to discover a unique metabolic dependency of Ewing's Sarcoma cells, and how this newfound knowledge has led to further preclinical research that exploits this metabolic vulnerability, significantly reducing the growth rate of Ewing Sarcoma tumor cells.
Ewings U: Erin Murphy, MD | The Use of SBRT In Pediatric Solid Tumors
EPISODE THREE: On August 9, 2022, The Little Warrior Foundation + Dr. Erin Murphy of the Cleveland Clinic discussed the use of SBRT in pediatric sarcoma patients. This post contains video, transcript and patient resources.