The Geisel School of Medicine Events Calendar

To view Grand Rounds at another time visit the following link: https://video.dartmouth-hitchcock.org/category/Grand+Rounds%3EPediatric/86113381

Co-Sponsored by Department of Medical Education & Dartmouth Health Office of Research Operations.
Tasha R. Wyatt, PhD

Co-Sponsored by Department of Medical Education & Dartmouth Health Office of Research Operations.
Anna Cianciolo, PhD

Please join us for our April Implementation Science Works in Progress session with Caitlin Howe, PhD, Assistant Professor of Epidemiology. Dr. Howe's research focuses on toxic metal exposures and their impacts on maternal and child health, with a particular interest in effects on early life growth and cardiometabolic health.

Discovery Science Seminar Series
Monday, April 1, 2024
12:15pm - 1:15pm
DCC Auditorium H

“Malignant transformation and therapeutic targeting of the immune system”

Ari M. Melnick, MD
Gebroe Professor of Hematology and Medical Oncology
Joan and Sanford Weill Department of Medicine
Professor of Immunology and Pharmacology
Weill Cornell Medicine

Host: Prerna Malaney, PhD

Any questions please email Jenni.Hinsley@dartmouth.edu or Amy.L.Potter@dartmouth.edu.

Co-Sponsored by Department of Medical Education & Dartmouth Health Office of Research Operations
Anna Cianciolo, PhD

Co-sponsored by Department of Medical Education & Dartmouth Health Office of Research Operations.
Tasha Wyatt, PhD

Anil K. Ojha, Ph.D.
Wadsworth Center,
NY State Dept. of Health
Associate Professor, Biomedical Sciences, School of Public Health, University at Albany
New York

Host: George O’Toole

“Visualizing non-replicating persisters of Mycobacterium tuberculosis in lung lesions”

Monday, April 1, 2024 @ 3PM
Chilcott Auditorium - Vail 120

In-person Only

Albert Koong, MD, PhD
Chair and Division Head, Radiation Oncology
MD Anderson
Presents: Regulations of Ferroptosis by IRE1: Implications for Cancer Therapy

Laura Solt, Ph.D.
Associate Professor of
Immunology and Microbiology
Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology
Jupiter, Florida

Host: Yina Huang

“Mechanisms of REV-ERB-dependent heme signaling in Th17 cells”

Monday, April 15, 2024 @ 11AM
Moved from Aud. H to Borwell 658W

Or Via ZOOM
https://dartmouth.zoom.us/j/99411458598?pwd=TThlanExb1hkV2h1czNJcUxGVTFSdz09
MEETING ID: 994 1145 8598
PASSCODE: 343665

Join us on April 3rd at the Hanover Inn Grand Ballroom for the Inaugural Dartmouth Symposium on Precision Health & AI. A distinguished group of Dartmouth AI experts and clinicians from across the campus will share their research, ideas, and breakthroughs with students, faculty, and staff at the CPHAI Symposium. Among other speakers, President Sian Beilock will give the opening remarks, followed by keynote speakers Dr. Curtis Langlotz, Stanford Professor and current President of the Radiological Society of North America, renowned for his pioneering work in applying AI in medical imaging, and Dr. Faisal Mahmood, Associate Professor at Harvard Medical School, who is renowned for his work in digital pathology and using AI in cancer diagnosis, prognosis, and biomarker discovery.

Rong Li, Ph.D.
Professor and Chair,
Department of Biochemistry & Molecular Medicine
Ross Professor of Basic Science Research
School of Medicine & Health Sciences
The George Washington University
Washington, DC

Host: Tyler Curiel

“BRCA1 and R-LoopFunctions In Breast Epithelial Cells and T Lymphocytes”

Monday, April 22, 2024 @ 3PM
Borwell 658W

Or Via ZOOM
https://dartmouth.zoom.us/j/99411458598?pwd=TThlanExb1hkV2h1czNJcUxGVTFSdz09

MEETING ID: 994 1145 8598
PASSCODE: 343665

Discovery Science Seminar Series
Monday, April 15, 2024
12:00pm - 1:00pm
Chilcott Auditorium

“The nucleolus, microRNAs and the human brain”

Susan Baserga, MD, PhD
William H. Fleming MD Professor of Molecular Biophysics & Biochemistry
Yale University

Host: Prerna Malaney, PhD

Any questions please email Jenni.Hinsley@dartmouth.edu or Amy.L.Potter@dartmouth.edu.

March 19, 2024
Aud. E
Melanie Wilcox, PhD, ABPP

8:00 AM - 9:00 AM Grand Rounds
Multicultural Orientation in Clinical Supervision: State of the Evidence

9:00 AM -11:00 AM Faculty Development Event
Enhancing Your Multicultural Orientation within Clinical Supervision

WebEx Information (Grand Rounds Only):
• https://dhvideo.webex.com/dhvideo/j.php?MTID=m69944e9bc3bf6bc22f2274cadf6a8442
• Meeting Number / Access Code: 2624 911 9197
• Password: JVd6UvbzC36
• Join By Phone: 1-408-792-6300 Call-in toll number

April 2, 2024
WebEx Only
Samuel Kohrman, MD
Somatic Symptom Disorder: Worried Well or Misunderstood Ill

WebEx Information:
• https://dhvideo.webex.com/dhvideo/j.php?MTID=m69944e9bc3bf6bc22f2274cadf6a8442
• Meeting Number / Access Code: 2624 911 9197
• Password: JVd6UvbzC36
• Join By Phone: 1-408-792-6300 Call-in toll number

April 16, 2024
WebEx Only
Carolyn Rodriguez, MD, PhD
Quieting the Obsessive Mind: Novel Interventions for OCD

WebEx Information:
• https://dhvideo.webex.com/dhvideo/j.php?MTID=m69944e9bc3bf6bc22f2274cadf6a8442
• Meeting Number / Access Code: 2624 911 9197
• Password: JVd6UvbzC36
• Join By Phone: 1-408-792-6300 Call-in toll number

April 23, 2024
WebEx Only
Adrian Jacques H Ambrose, MD, MPH, FAPA
E3 of AI: Equity, Errors, and Ethics of Artificial Intelligence and Mental Health

WebEx Information:
• https://dhvideo.webex.com/dhvideo/j.php?MTID=m69944e9bc3bf6bc22f2274cadf6a8442
• Meeting Number / Access Code: 2624 911 9197
• Password: JVd6UvbzC36
• Join By Phone: 1-408-792-6300 Call-in toll number

April 30, 2024
WebEx Only
Hannah Roggenkamp, MD
Moral People Facing Immoral Situations - Military and Healthcare Perspectives on Moral Injury

WebEx Information:
• https://dhvideo.webex.com/dhvideo/j.php?MTID=m69944e9bc3bf6bc22f2274cadf6a8442
• Meeting Number / Access Code: 2624 911 9197
• Password: JVd6UvbzC36
• Join By Phone: 1-408-792-6300 Call-in toll number

Discovery Science Seminar Series
Monday, April 29, 2024
12:00pm - 1:00pm
Kellogg 200

“Super-sized cells and not-so-silent codons in organ development”

Don Fox, PhD
Professor of Pharmacology & Cancer Biology
Co-Director of the Regeneration Center
Duke University

Host: Jamie Moseley, PhD

Any questions please email Jenni.Hinsley@dartmouth.edu or Amy.L.Potter@dartmouth.edu.

Geisel School of Medicine at Dartmouth
Guarini School of Graduate and Advanced Studies
Microbiology and Immunology
Graduate Program
THESIS DEFENSE

Alia Sajani

“Heterogeneity and plasticity of the naïve CD4+ T cell compartment”

Friday, April 12, 2024
9:00A.M.

Auditorium H (DH)

Zoom https://dartmouth.zoom.us/j/98751493800?pwd=RkVXRkxiTW82T3UwVFJBVlF2MGpoUT09
Meeting ID: 987 5149 3800
Passcode: Thesis

Advisors: Randolph Noelle and Mary Jo Turk

Geisel School of Medicine at Dartmouth
Guarini School of Graduate and Advanced Studies
Microbiology and Immunology
Graduate Program

THESIS DEFENSE

Rebecca Valls

“Establishmentof Bacteroides in the gut and its role in the CF gut-lung axis”

Wednesday, April 17, 2024
10:00A.M.

Chilcott Auditorium

Zoom https://dartmouth.zoom.us/j/93269992381?pwd=RGoxTE1pUjd5RXkvRmF6U1JoOWtPQT09
Meeting ID: 932 6999 2381
Passcode: Thesis

Advisor: George O'Toole

Geisel School of Medicine at Dartmouth
Guarini School of Graduate and Advanced Studies
Microbiology and Immunology
Graduate Program

THESIS DEFENSE

Jordan Fredriksen Isaacs

“UncouplingCD39 from CD8+ T cell exhaustion”

Friday,April 19, 2024
10:00A.M.
Auditorium G (DH)

Zoom https://dartmouth.zoom.us/j/96660052889?pwd=VUJlK1ltU0ExV2VqT3lPR1dKWFpXQT09
Meeting ID: 966 6005 2889
Passcode: Thesis

Advisor: Pamela Rosato

Geisel School of Medicine at Dartmouth
Guarini School of Graduate and Advanced Studies
Microbiology and Immunology
Graduate Program

THESIS DEFENSE

Leena Abdullah

“Hierarchal single-cell lineage tracing reveals differential fate commitment of CD8 T-cell clones in response to acute infection”

Thursday, May 2, 2024
10:00 A.M.
Auditorium E (DHMC)

Zoom https://dartmouth.zoom.us/j/98111834184?pwd=N2ZlRTE3b2dMaHQyMFZwMENRM1c0Zz09
Meeting ID: 981 1183 4184
Passcode: Thesis

Advisor: Yina Huang

Jessica Blackburn, PhD
Associate Professor, University of Kentucky
Presents: Zebrafish models uncover targetable mechanisms of T-c ell Acute Lymphoblastic Leukemia self-renewal

Audrey Calderwood, MD, MS
Associate Professor of Medicine, Geisel
Presenting: De-escalation of low value cancer preventive services: colon polyp surveillance

Topics Covered
• Describe and discuss a variety of active learning strategies that can be used in medical education.
• Learn how to develop an active learning session plan of instruction.
• Practice developing active learning strategies in a mini-workshop format.
• Share ideas within the group to support collaborative learning.

Geisel School of Medicine at Dartmouth
Guarini School of Graduate and Advanced Studies
Microbiology and Immunology
Graduate Seminar

"Regulation of the magnitude and duration of the immune response"

PRESENTED BY
Carla Rothlin, Ph.D.
PROFESSOR
Yale University
New Haven, CT

HOST: Alia Sajani

Friday, April 12, 2024
2:00 P.M.

Auditorium G (DHMC)

Dartmouth Geisel School of Medicine
Microbiology and Immunology
Seminar Series Presents Outside Examiner

Chris van der Gast, Ph.D.
Northumbria University
Newcastle

"Impacts of CFTR modulators on the CF gut microbiome"

Tuesday, April 16, 2024
Kellogg 100
3:00 PM

In person only

Hosted by: Rebecca A. Valls and George A. O'Toole, Ph.D.

Geisel School of Medicine at Dartmouth
Guarini School of Graduate and Advanced Studies
Microbiology and Immunology
Graduate Seminar

"Controlof lung CD4+ T cell responses by eATP receptors"

PRESENTED BY

Henrique Borges da Silva, Ph.D.
Assistant Professor
Mayo Clinic
Scottsdale, AZ

https://www.mayo.edu/research/faculty/borges-da-silva-henrique-ph-d/bio-20492923

HOST: Jordan Fredriksen Isaacs

Friday, April19, 2024
2:00 P.M.
Auditorium G
DHMC

Child Maltreatment Prevention: New Approaches to an Old Problem
Philip Scribano, DO
Section Chief of Safe Place: The Center for Child Protection and Health, Children's Hospital of Philadelphia
Professor of Clinical Pediatrics, Perelman School of Medicine
Shield Our Children from Harm Speaker

To view Grand Rounds at another time visit the following link: https://video.dartmouth-hitchcock.org/category/Grand+Rounds%3EPediatric/86113381

Newborn provider perspectives when asked by a mother to not share their infant’s prenatal substance exposure.
Colby Kearl, MD
Neonatal Fellow
Dartmouth Health Children’s

To view Grand Rounds at another time visit the following link: https://video.dartmouth-hitchcock.org/category/Grand+Rounds%3EPediatric/86113381

Duncan Morhardt, MD
Pediatric Surgery
Dartmouth Health Children’s

To view Grand Rounds at another time visit the following link: https://video.dartmouth-hitchcock.org/category/Grand+Rounds%3EPediatric/86113381

Improving Pediatric Readiness in the Community: How can we ensure every child receives the standard of care?
Anna Bauman, MD
Pediatric Resident
Dartmouth Health Children’s

To view Grand Rounds at another time visit the following link: https://video.dartmouth-hitchcock.org/category/Grand+Rounds%3EPediatric/86113381

Medicine Grand Rounds
Friday, April 5, 2024
8:00 a.m. - 9:00 a.m.

“Environmental Exposures and Respiratory Health Outcomes”

Laura Paulin, MD
Assistant Professor of Medicine and Epidemiology
Geisel School of Medicine at Dartmouth
Staff Physician, Section of Pulmonary and Critical Care Medicine
Dartmouth-Hitchcock Medical Center

You may attend virtually via the livestream link:
http://med.dartmouth-hitchcock.org/education/dept_medicine_grand_rounds_live.html

Graduate Program in Biochemistry & Cell Biology
Ph.D. Thesis Presentation
Muhammad Abubakar Khan
Friday May 3, 2024
10:00 AM ET
In-Person: Chilcott Auditorium

"Understanding the non-canonical regulation of SREBP in Aspergillus fumigatus"

Research Advisors: Dean Madden, PhD

If you would like to receive the link and password for this Zoom meeting, please email Jenni.Hinsley@dartmouth.edu

"What is this "impact" we seek to measure? Toward a more meaningful impact-tracking strategy for medical education research."

Join Zoom Meeting
https://dartmouth.zoom.us/j/95705826490?pwd=YkluakZpempsL21pbTBVL2JJSncrUT09

"Identifying structural determinants of medical student well-being with wearable devices"

Join Zoom Meeting
https://dartmouth.zoom.us/j/97385239961?pwd=RGtYS1laWVZGNlNVTEk2K2UzaCsvUT09

Akhenaton-Andrew Dhafir Jones III, Ph.D.
Assistant Professor of
Civil and Environmental Engineering
Pratt School of Engineering
Duke University
Durham, NC

Host: George O’Toole/Shawna Pratt

“Defending the colony: new physical and mathematical tools for studying Pseudomonas aeruginosa biofilms”

Monday, April 29, 2024 @ 3PM
Chilcott Auditorium - Vail 120

In-person Only

Geisel School of Medicine at Dartmouth
Guarini School of Graduate and Advanced Studies
Microbiology and Immunology
Graduate Program

THESIS DEFENSE

Haleema Sadia Malik

“Mechanistic Insights into Positive Regulation of the Pyrin Inflammasome in Macrophages”

Thursday, April 18, 2024
9:00 A.M.
Chilcott Auditorium

Zoom
https://dartmouth.zoom.us/j/96350982605?pwd=cGdOdTA4ZGxCaDNCeHJZakhOWll3QT09

Meeting ID: 963 5098 2605
Passcode: Thesis

Advisor: James Bliska

Neurology Grand Rounds, Auditorium H and Livestream
Topic: Epilepsy and Alzheimer Disease
Speaker: Krzysztof Bujarski, MD, Epilepsy Section Chief, Dartmouth Hitchcock Medical Center

John R. Desjarlais
Executive Vice President,
Research & Chief Scientific Officer
Xencor
465 North Halstead Street, Suite 200
Pasadena, CA

Host: Tyler Curiel

“Bispecific antibodies to promote T cell signals 1 and 2 for the treatment of solid tumors”

Tuesday, April 9, 2024 @ 10AM
Auditorium G (DH Complex)

Or Via ZOOM
https://dartmouth.zoom.us/j/99411458598?pwd=TThlanExb1hkV2h1czNJcUxGVTFSdz09

MEETING ID: 994 1145 8598
PASSCODE: 343665

Auditorium E and Livestream
Topic: AI & Teaching in Neurology
Presented by: Erik Kobylarz, MD, PhD, Clinical Neurophysiology Fellowship Director, Intraoperative Neurophysiologic Monitoring Director, Dartmouth Hitchcock Medical Center and Thomas Thesen, PhD, Associate Professor of Medical Education, Co-Director, Neuroscience & Neurology - MD Program, Co-Director, Medical Learning Sciences - MD Program, Dartmouth Geisel School of Medicine

The Department of Biomedical Data Science at Geisel invites you to attend a Grand Rounds presentation by Jeremy Taylor, PhD, Professor of Biostatistics and Radiation Oncology, University of Michigan School of Public Health, on Thursday, April 11 from 12:00-1:00pm at DHMC, Auditorium H (or via Zoom).


Talk title: “Estimation and interpretation of time-varying effects of demographic, tumor, access to care and SES factors in cancer survival studies”

Host: Tor Tosteson, ScD

Location: In-person at DHMC, Auditorium H or via Zoom (no registration required)

Please see link below for more details.

Zoom meeting ID: 503 779 5102

Zoom passcode: 6501974

URL: https://dartmouth.zoom.us/j/5037795102

Phone (if needed for audio only, or to join by phone only): 669-900-6833


Presentation Summary
There have been thousands of studies that used the Cox proportional hazards model to analyze data and assess the association between factors measured at the time of diagnosis and survival outcomes in patients diagnosed with cancer. The Cox model makes the assumption of proportional hazards, but a more general model may give a more accurate description of the data. In a more flexible model, the hazard ratio associated with any factor can be allowed to vary over time. In this talk I will describe how we overcame the computational and statistical challenges of fitting such a model when the datasets are extremely large. I will then use the model to examine data from the SEER and NCDB cancer registries. I will take a pan cancer approach and consider 14 different cancer types. For SEER I consider a basic set of standard factors (age, race, stage, year of diagnosis, gender) and two outcomes, either death due to cancer or death due to other causes. The analyses reveal some substantial time-varying associations, especially for stage and age. The NCDB registry only has death from any cause, but it has additional factors, including comorbidities, SES variables and access to care variables. We investigate whether the time-varying age effect can be explained by other factors. The answer is generally no. I will invite the audience to speculate on possible reasons for the time varying association with age.


Biography
Jeremy M. G. Taylor, PhD, is the Pharmacia Professor of Biostatistics at the University of Michigan School of Public Health. He obtained a bachelor’s degree in mathematics and a diploma in statistics from Cambridge University, and a PhD in statistics from University of California-Berkeley. He was a faculty member in the Department of Biostatistics and the Department of Radiation Oncology at UCLA from 1983 to 1998. He is currently a faculty member in the Department of Biostatistics, the Department of Radiation Oncology, and the Department of Computational Medicine and Bioinformatics, and the Director of the Center for Cancer Biostatistics at the University of Michigan School of Public Health. Dr. Taylor is the winner of the Michael Fry Award from the Radiation Research Society, the Mortimer Spiegelman Award from the American Public Health Association, the Jerome Sacks Award from the National Institute of Statistical Science, and the Samuel Wilks award from the American Statistical Association. He is a former chair of the Biometrics Section of the American Statistical Association (ASA) and a fellow of the ASA. Dr. Taylor is the former chair of the Biostatistical Methods and Research Design grant review committee for the National Institutes of Health, and he was one of the coordinating editors of Biometrics from 2012-2014. He has over 400 publications and research interests in longitudinal and survival data, cure models, methods for missing data, causal inference, biomarkers, surrogate and auxiliary variables, and data integration. Dr. Taylor worked previously in AIDS research, but currently he mainly focuses on cancer research. He has served as the dissertation chair for 41 PhD students in biostatistics at UCLA and the University of Michigan.

Department of Surgery Grand Rounds
Friday, May 3, 2024
7:00–8:00 AM
Auditorium H

“Transcriptional Mechanisms That Establish Breast Cancer Molecular Phenotype”

Speaker:
Ronald J. Weigel, MD, PhD, MBA
EA Crowell Jr. Professor and Chair, Department of Surgery
University of Iowa
Medical Director, American College of Surgeons Cancer Programs

Geisel School of Medicine at Dartmouth
Guarini School of Graduate and Advanced Studies
Microbiology and Immunology
Graduate Program

THESIS DEFENSE

Kaesi A. Morelli

“Low Oxygen Adaptation and Biofilm Development in the Pathogenic Mold Aspergillus fumigatus”

Wednesday, May 1, 2024
10:00 A.M.
Chilcott Auditorium

Zoom
https://dartmouth.zoom.us/j/99668122144?pwd=d2kvM1NVbkh3Ynk4U1Q1L3ByT1JVZz09

Meeting ID: 996 6812 2144
Passcode: Thesis

Advisor: Robert Cramer

Auditorium E and Livestream.
Topic: The Physician’s Dilemma: Economic analysis of training and working as a healthcare professional
Speaker: Molly Perkins, MD, Neurology Chief Resident

Preventing Overdiagnosis Webinar: Why cancer is our most feared disease.

Learning objectives:
•Emphasize the importance of the psychology of risk perception for the study of the contributors to overscreening and overdiagnosis.
•Highlight specific ways risk perception contributes to the harms caused by cancer overdiagnosis and overtreatment.
•Stimulate discussion of behavioral economics-like approaches to apply the understanding of these psychological factors to shape the “choice architecture” influencing people’s decisions about screening and treatment of overdiagnosed cancer.

The talk will be presented by David Ropeik, award winning journalist, former Director of Communications for the Center for Risk Analysis at the Harvard School of Public Health, and author of Curing Cancerphobia: How Risk, Fear, and Worry Mislead Us. (Johns Hopkins University Press, 2023).

Preventing Overdiagnosis is an international organization which aims to develop, organize and communicate research about overdiagnosis and overtreatment. It is sponsored by Oxford University (UK), Wiser Healthcare (Australia), The Danish College of General Practitioners, and the Dartmouth Institute (USA).

Please join the Dartmouth Center for Implementation Science for our April Fundamentals seminar with Katharine Rendle, PhD. MPH, MSW (UPenn). Dr. Rendle will be presenting: Measuring Implementation Context, Process, & Outcomes.

Dartmouth Geisel School of Medicine
Dartmouth Guarini School of Graduate and Advanced Studies
Microbiology and Immunology
Graduate Seminar

Presented By

Nikhil S. Joshi, Ph.D.
Associate Professor of Immunobiology
Yale School of Medicine
New Haven, CT

Host: Leena Abdullah

“Investigating T cell immunobiology using genetically engineered models”

Thursday, May 2, 2024 @ 2PM
Auditorium E (DH Complex)

Or Via ZOOM
https://dartmouth.zoom.us/j/2378478897?omn=98704950505

MEETING ID: 237 847 8897
PASSCODE: GRADSEM