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Effectiveness and Safety of Semaglutide for Weight Loss in Patients With Inflammatory Bowel Disease and Obesity
Aakash Desai and others
Background Semaglutide, a glucagon-like peptide-1 receptor agonist, has shown sustained and clinically significant weight loss in the general population. There are limited data on outcomes of its use ...
Exploring the Predictive Value of Gut Microbiome Signatures for Therapy Intensification in Patients With Inflammatory Bowel Disease: A 10-Year Follow-up Study
Zainab M A Al Radi and others
Background Inflammatory bowel diseases (IBDs) pose a significant challenge due to their diverse, often debilitating, and unpredictable clinical manifestations. The absence of prognostic tools to ...
Inequalities in Healthcare Access, Experience and Outcomes in Adults With Inflammatory Bowel Disease: A Scoping Review
Rachel L Hawkins and others
Background Inflammatory bowel diseases (IBDs) are incurable diseases that require lifelong access to health services. Accumulating evidence of inequalities in health care access, experience, and ...
Bowel Damage and Disability in Crohn’s Disease: Is it Really Two Birds with One Stone?
Tommaso Innocenti and Gabriele Dragoni
In 1976, the World Health Organization (WHO) defined disability as “any restriction or lack (resulting from an impairment) of ability to perform an activity in the manner or within the range ...
Changes Over Time in the Lémann Index and the Inflammatory Bowel Disease Disability Index in a Prospective Cohort of Patients With Crohn’s Disease
Laurine Cartier and others
Background Crohn’s disease (CD) is a progressive, destructive, and disabling disorder. Our study aimed to assess changes over time in the Lémann index (LI) and the Inflammatory Bowel Disease ...
Tofacitinib as a Rescue Therapy for Ulcerative Colitis in Pregnancy
Catherine Rowan and others
Tofacitinib, a potentially teratogenic nonselective Janus Kinase inhibitor was used as salvage therapy for ulcerative colitis during pregnancy with corticosteroids, maintenance ustekinumab, and ...
Ustekinumab Offers Long-Term Clinical Remission With Safety in Very Early-Onset Inflammatory Bowel Disease
Itaru Iwama and others
We observed efficacy and safety of ustekinumab in very early-onset inflammatory bowel disease, which has not been previously reported. Clinical remission at 52% was 75%, often persisting beyond 2 ...
Intestinal Stromal Cells in the Turmoil of Inflammation and Defective Connective Tissue Remodeling in Inflammatory Bowel Disease
Ioannis Drygiannakis and others
In steady state, intestinal subepithelial myofibroblasts form a thin layer below the basement membrane. Unlike the rest of the stromal cells in the lamina propria, they express tensile proteins, ...

Editor's Choice Articles

Characterization of the Gut Microbiota and Mycobiota in Italian Pediatric Patients With Primary Sclerosing Cholangitis and Ulcerative Colitis
Federica Del Chierico and others
Background Primary sclerosing cholangitis (PSC) is a chronic, fibroinflammatory, cholestatic liver disease of unknown etiopathogenesis, often associated with inflammatory bowel diseases. Recent ...
Microbial and Metabolite Signatures of Stress Reactivity in Ulcerative Colitis Patients in Clinical Remission Predict Clinical Flare Risk
Jonathan P Jacobs and others
Background Stress reactivity (SR) is associated with increased risk of flares in ulcerative colitis (UC) patients. Because both preclinical and clinical data support that stress can influence gut ...
Serum and Urine Metabolomic Profiling of Newly Diagnosed Treatment-Naïve Inflammatory Bowel Disease Patients
Laila Aldars-García and others
Background and Aims Inflammatory bowel disease (IBD) is a prevalent chronic noncurable disease associated with profound metabolic changes. The discovery of novel molecular indicators for unraveling ...
Prediction of Response to Systemic Corticosteroids in Active UC by Microbial Composition—A Prospective Multicenter Study
Andreas Blesl and others
In this prospective study, patients with active ulcerative colitis receiving systemic corticosteroids were included (n  = 93). Baseline microbial diversity and composition were associated with response to treatment only in biologic-naïve patients. Responders experienced longitudinal restoration of microbial composition and function.
Geography Influences Susceptibility to SARS-CoV-2 Serological Response in Patients With Inflammatory Bowel Disease: Multinational Analysis From the ICARUS-IBD Consortium
Serre-Yu Wong and others
Background Beyond systematic reviews and meta-analyses, there have been no direct studies of serological response to COVID-19 in patients with inflammatory bowel disease (IBD) across continents. In ...
Pro-inflammatory Cytokines Promote the Occurrence and Development of Colitis-associated Colorectal Cancer by Inhibiting miR-615-5p
Danping Sun and others
Background Patients with ulcerative colitis (UC) may be prone to colitis-associated colorectal cancer (CAC), but there is still a poor understanding of the underlying mechanism so far. This study ...
Health Care Disparities, Social Determinants of Health, and Emotional Impacts in Patients with Ulcerative Colitis: Results from a Global Ulcerative Colitis Narrative Patient Survey
Florence-Damilola Odufalu and others
Background The Ulcerative Colitis (UC) Narrative global survey assessed aspects of living with UC. This analysis aimed to identify health care disparities, social determinants of health, and ...
Clinical Validation of a Capillary Blood Home-Based Self-Sampling Technique for Monitoring of Infliximab, Vedolizumab, and C-Reactive Protein Concentrations in Patients With Inflammatory Bowel Disease
Antonius T Otten and others
Background Therapeutic drug monitoring provides important guidance for treatment of patients with inflammatory bowel disease (IBD) and could help to early identify treatment failure. This study aimed ...

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4.9

Editor-in-Chief

Fabio Cominelli, M.D., Ph.D.

Deputy Editor

Sonia Friedman, M.D.

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Thiopurine treatment in ulcerative colitis: a critical review of the evidence for current clinical practice

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A survey study of gastroenterologists' attitudes and barriers towards therapeutic drug monitoring of anti-TNF therapy in inflammatory bowel disease

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Indeterminate QuantiFERON-TB gold increases likelihood of inflammatory bowel disease treatment delay and hospitalization

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Factors associated with length of stay in veterans with inflammatory bowel disease hospitalized for an acute flare

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